Based on the practice of the discipline construction of college of computing & informatics at Drexel University, this article analyzes the development concept of LIS under the integration of computational science and informatics. Starting from the three dimensions of education systems, academic research and social practice, the authors illustrate the construction content of LIS under the integration of computational science and informatics. At the same time, we summarize the enlightenments combining with the current situation of the development of LIS in China.