This article constructs an interdisciplinary network covering 156 discipline orientations, and analyzes the interdisciplinary state of domain knowledge and the impact of interdisciplinary on the research status of domain knowledge. The results show that the interdisciplinary phenomenon in domain knowledge has a certain degree of small world characteristics and approximate scale-free distribution characteristics; the interdisciplinary has a strong positive correlation with the number of subject publications; the interdisciplinary is less relevant to high-level papers in domain knowledge.