[Purpose/significance] Design a multi-dimensional and multi-level comprehensive governance framework for online health rumors to curb the spread and misuse of online health rumors. [Method/process] By abstracting the dissemination process of online health rumors and the blocking methods at each stage of dissemination, the main stages and key points of online health rumors governance are summarized and analyzed. Then, following the characteristics of health rumors generation and dissemination, each stage's governance objectives, governance targets, and governance measures are analyzed in detail, and a closed-loop governance framework is derived accordingly. [Result/conclusion] The governance framework mainly includes one core technology module (content identification technology model) and three central platforms modules (the platform for the online media, the platform for the rumor-refuting experts and the platform for sharing rumor-refuting information), which basically covers the core issues that need to be considered in current online health rumors governance. It can serve as the top-level design foundation and action guide for health ru⁃ mors governance activities.