[Purpose/significance] This study aims to systematically integrate and theoretically analyze practical expe⁃riences in infodemic management. It seeks to enrich the theoretical landscape and optimize the efficacy of practical in⁃terventions. [Method / process] A web-based survey method was employed to collect infodemic management initia⁃tives implemented by major international bodies, including UNESCO, the World Health Organization and the Europe⁃an Commission. Utilizing qualitative research methodologies, these beneficial practices were systematically integrated following a rigorous procedure of "material selection, discretization, and item clustering" to extract management strate⁃gies for infodemics. These strategies underwent theoretical analysis to elucidate their application principles. Guided by these principles, a two-dimensional "stage-countermeasure" matrix was adopted as an analytical framework to dissect the application methods of these strategies. [Result/conclusion] The study proposes a systematic response framework for infodemics comprising "management strategies-application principles-application methods". The management strategies are categorized into four dimensions: strategies targeting information source elements, information content ele⁃ments, information receiver elements, and environmental optimization. The application of these strategies should adhere to principles such as contextual adaptability, curve flattening, rapid response, proactive prevention, sustained effort, and collaborative synergy. Furthermore, it is imperative to align strategies with the evolutionary stages of the infodemic, prior⁃itizing distinct combinations of strategies based on the specific characteristics of each stage.